A Heterocyclic Pyrrolopyrimidine Compound as a Possible Candidate for Topical Application to Induce Hair Restoration

Established from previous studies, a heterocyclic pyrrolopyrimidine (PyP) compound increases endogenous stem cell proliferation. Here, we utilized a topical PyP to increase cell proliferation of cells responsible for hair production. Varying doses (0.75, 1.5, 3.0 mg/ml) were applied to shaved, dorsal regions of mice for 5 consecutive days. Bromodeoxyuridine (100 mg/kg/day, i.p.) was injected on days 4 and 5 to identify proliferating cells. The PyP dose-dependently increased hair growth and cell proliferation within the subcutaneous region of the epidermis. This data suggests the PyP compound has the potential to be a novel compound for hair restoration.